Naringenin is a flavonoid from grapefruit and other citrus fruits. Most people get it through its glycoside form, naringin. The compound acts as an antioxidant, shielding cells from oxidative stress.
People take naringenin supplements to help maintain heart health and support blood sugar levels that are already in a normal range. It does this by affecting enzymes and metabolic pathways that handle fats and glucose.
The compound is fat soluble. Taking it with a meal boosts absorption and can cut down the chance of stomach upset. Watch out with this one, though. Naringenin blocks the CYP3A4 enzyme, the same way grapefruit juice does, so it can disrupt how your body processes many medications.