Polygonum cuspidatum root extract concentrates resveratrol and other stilbenoids from Japanese knotweed rhizome. Traditional Chinese medicine uses the plant, called Hu Zhang, to support healthy inflammatory responses and liver function.
Modern supplement formulas rely on this standardized extract for a consistent resveratrol dose. People take it to target joint comfort, cardiovascular wellness, and immune resilience.
Take the extract with a meal that includes about 10 g of dietary fat to boost absorption. Morning or lunchtime doses are common. This botanical can interact with drugs processed by CYP450 enzymes, including some statins, antidepressants, and blood thinners. Avoid it during pregnancy and breastfeeding and check with a healthcare provider before starting.