SAMe (S-Adenosylmethionine) is a natural compound your body produces. It participates in methylation, which helps regulate mood and joint health. Many people take it to support emotional balance and joint comfort.
If your SAMe levels are low, supplementing may help maintain mood and joint function. Take it on an empty stomach, starting with a low dose and increasing gradually as needed.
Do not take SAMe if you have active liver disease or hepatic impairment. Its safety during pregnancy and breastfeeding is not known. SAMe can interact with antidepressants, raising the risk of serotonin syndrome. It may also interact with other medications.